The effect of ultrasound on osteogenesis in the vertically distracted edentulous mandible. A double-blind trial
Identifieur interne : 006512 ( Main/Exploration ); précédent : 006511; suivant : 006513The effect of ultrasound on osteogenesis in the vertically distracted edentulous mandible. A double-blind trial
Auteurs : J. Schortinghuis [Pays-Bas] ; A. L. J. J. Bronckers [Pays-Bas] ; J. Gravendeel [Pays-Bas] ; B. Stegenga [Pays-Bas] ; G. M. Raghoebar [Pays-Bas]Source :
- International journal of oral and maxillofacial surgery [ 0901-5027 ] ; 2008.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Avancement mandibulaire (), Cal osseux (cytologie), Cal osseux (physiologie), Humains, Implants dentaires, Mandibule (cytologie), Mandibule (physiologie), Mâchoire édentée (rééducation et réadaptation), Méthode en double aveugle, Ostéogenèse par distraction (), Pose d'implant dentaire endo-osseux, Régénération osseuse (physiologie), Résorption alvéolaire (), Résorption alvéolaire (rééducation et réadaptation), Sujet âgé, Ultrasonothérapie (), Études longitudinales.
- MESH :
- cytologie : Cal osseux, Mandibule.
- physiologie : Cal osseux, Mandibule, Régénération osseuse.
- rééducation et réadaptation : Mâchoire édentée, Résorption alvéolaire.
- Pascal (Inist)
- Adulte d'âge moyen, Avancement mandibulaire, Edentation, Exploration ultrason, Echographie, Chirurgie, Humains, Implants dentaires, Méthode en double aveugle, Ostéogenèse par distraction, Pose d'implant dentaire endo-osseux, Résorption alvéolaire, Sujet âgé, Ultrason, Ostéogenèse, Mandibule, Etude double insu, Essai clinique, Traitement, Stomatologie, Ultrasonothérapie, Études longitudinales.
- Wicri :
- topic : Chirurgie.
English descriptors
- KwdEn :
- Aged, Alveolar Bone Loss (rehabilitation), Alveolar Bone Loss (surgery), Bone Regeneration (physiology), Bony Callus (cytology), Bony Callus (physiology), Clinical trial, Dental Implantation, Endosseous, Dental Implants, Double blind study, Double-Blind Method, Echography, Edentulousness, Humans, Jaw, Edentulous (rehabilitation), Longitudinal Studies, Mandible, Mandible (cytology), Mandible (physiology), Mandibular Advancement (methods), Middle Aged, Osteogenesis, Osteogenesis, Distraction (methods), Sonography, Stomatology, Surgery, Treatment, Ultrasonic Therapy (methods), Ultrasound.
- MESH :
- chemical : Dental Implants.
- cytology : Bony Callus, Mandible.
- methods : Mandibular Advancement, Osteogenesis, Distraction, Ultrasonic Therapy.
- physiology : Bone Regeneration, Bony Callus, Mandible.
- rehabilitation : Alveolar Bone Loss, Jaw, Edentulous.
- surgery : Alveolar Bone Loss.
- Aged, Dental Implantation, Endosseous, Double-Blind Method, Humans, Longitudinal Studies, Middle Aged.
Abstract
Whether low intensity pulsed ultrasound therapy stimulates osteogenesis in mandibular distraction was investigated in a double-blind trial. Nine patients underwent a vertical mandibular distraction over a distance of 5.1 ± 1.2 mm. Ultrasound or placebo therapy was started daily from the first day of distraction. After 46 ± 8.1 days consolidation, two endosseous implants were inserted and a transmandibular biopsy was taken. Ultrasonographs were taken regularly to follow osteogenesis inside the gap. There were no complications during the 44 ± 7.1 months of follow-up. Microradiographic measurements of the biopsies revealed no differences in the area of mineralized tissue in the distraction gap. The cranially distracted bone segment appeared significantly more radiolucent than the caudal bone. Histological examination showed large lacunae inside the cranially distracted bone segment, filled with clusters of osteoclasts and surrounded by clear tetracycline double labels. Within the distraction gap, woven bone was present, with no apparent differences between the treatment groups. Ultrasonographic follow-up revealed that osteogenesis inside the distraction gap progresses from 4 to 20 weeks post distraction, with no differences between the ultrasound and the placebo groups. In summary, ultrasound treatment does not appear to stimulate bone formation in the severely resorbed vertical distracted mandible.
Affiliations:
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A double-blind trial</title><author><name sortKey="Schortinghuis, J" sort="Schortinghuis, J" uniqKey="Schortinghuis J" first="J." last="Schortinghuis">J. Schortinghuis</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Oral and Maxillofacial Surgery, University of Groningen and University Medical Centre Groningen (UMCG)</s1><s3>NLD</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Department of Oral and Maxillofacial Surgery, University of Groningen and University Medical Centre Groningen (UMCG)</wicri:noRegion></affiliation></author><author><name sortKey="Bronckers, A L J J" sort="Bronckers, A L J J" uniqKey="Bronckers A" first="A. L. J. J." last="Bronckers">A. L. J. J. Bronckers</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Oral Cell Biology, Academic Centre for Dentistry</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Gravendeel, J" sort="Gravendeel, J" uniqKey="Gravendeel J" first="J." last="Gravendeel">J. Gravendeel</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Radiology, University of Groningen and University Medical Centre Groningen (UMCG)</s1><s3>NLD</s3><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Department of Radiology, University of Groningen and University Medical Centre Groningen (UMCG)</wicri:noRegion></affiliation></author><author><name sortKey="Stegenga, B" sort="Stegenga, B" uniqKey="Stegenga B" first="B." last="Stegenga">B. Stegenga</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Oral and Maxillofacial Surgery, University of Groningen and University Medical Centre Groningen (UMCG)</s1><s3>NLD</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Department of Oral and Maxillofacial Surgery, University of Groningen and University Medical Centre Groningen (UMCG)</wicri:noRegion></affiliation></author><author><name sortKey="Raghoebar, G M" sort="Raghoebar, G M" uniqKey="Raghoebar G" first="G. M." last="Raghoebar">G. M. Raghoebar</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Oral and Maxillofacial Surgery, University of Groningen and University Medical Centre Groningen (UMCG)</s1><s3>NLD</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Department of Oral and Maxillofacial Surgery, University of Groningen and University Medical Centre Groningen (UMCG)</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">International journal of oral and maxillofacial surgery</title><title level="j" type="abbreviated">Int. j. oral maxillofac. surg.</title><idno type="ISSN">0901-5027</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">International journal of oral and maxillofacial surgery</title><title level="j" type="abbreviated">Int. j. oral maxillofac. surg.</title><idno type="ISSN">0901-5027</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Alveolar Bone Loss (rehabilitation)</term><term>Alveolar Bone Loss (surgery)</term><term>Bone Regeneration (physiology)</term><term>Bony Callus (cytology)</term><term>Bony Callus (physiology)</term><term>Clinical trial</term><term>Dental Implantation, Endosseous</term><term>Dental Implants</term><term>Double blind study</term><term>Double-Blind Method</term><term>Echography</term><term>Edentulousness</term><term>Humans</term><term>Jaw, Edentulous (rehabilitation)</term><term>Longitudinal Studies</term><term>Mandible</term><term>Mandible (cytology)</term><term>Mandible (physiology)</term><term>Mandibular Advancement (methods)</term><term>Middle Aged</term><term>Osteogenesis</term><term>Osteogenesis, Distraction (methods)</term><term>Sonography</term><term>Stomatology</term><term>Surgery</term><term>Treatment</term><term>Ultrasonic Therapy (methods)</term><term>Ultrasound</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Avancement mandibulaire ()</term><term>Cal osseux (cytologie)</term><term>Cal osseux (physiologie)</term><term>Humains</term><term>Implants dentaires</term><term>Mandibule (cytologie)</term><term>Mandibule (physiologie)</term><term>Mâchoire édentée (rééducation et réadaptation)</term><term>Méthode en double aveugle</term><term>Ostéogenèse par distraction ()</term><term>Pose d'implant dentaire endo-osseux</term><term>Régénération osseuse (physiologie)</term><term>Résorption alvéolaire ()</term><term>Résorption alvéolaire (rééducation et réadaptation)</term><term>Sujet âgé</term><term>Ultrasonothérapie ()</term><term>Études longitudinales</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Dental Implants</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cal osseux</term><term>Mandibule</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Bony Callus</term><term>Mandible</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Mandibular Advancement</term><term>Osteogenesis, Distraction</term><term>Ultrasonic Therapy</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cal osseux</term><term>Mandibule</term><term>Régénération osseuse</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Bone Regeneration</term><term>Bony Callus</term><term>Mandible</term></keywords><keywords scheme="MESH" qualifier="rehabilitation" xml:lang="en"><term>Alveolar Bone Loss</term><term>Jaw, Edentulous</term></keywords><keywords scheme="MESH" qualifier="rééducation et réadaptation" xml:lang="fr"><term>Mâchoire édentée</term><term>Résorption alvéolaire</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Alveolar Bone Loss</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Dental Implantation, Endosseous</term><term>Double-Blind Method</term><term>Humans</term><term>Longitudinal Studies</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Avancement mandibulaire</term><term>Edentation</term><term>Exploration ultrason</term><term>Echographie</term><term>Chirurgie</term><term>Humains</term><term>Implants dentaires</term><term>Méthode en double aveugle</term><term>Ostéogenèse par distraction</term><term>Pose d'implant dentaire endo-osseux</term><term>Résorption alvéolaire</term><term>Sujet âgé</term><term>Ultrason</term><term>Ostéogenèse</term><term>Mandibule</term><term>Etude double insu</term><term>Essai clinique</term><term>Traitement</term><term>Stomatologie</term><term>Ultrasonothérapie</term><term>Études longitudinales</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Chirurgie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Whether low intensity pulsed ultrasound therapy stimulates osteogenesis in mandibular distraction was investigated in a double-blind trial. Nine patients underwent a vertical mandibular distraction over a distance of 5.1 ± 1.2 mm. Ultrasound or placebo therapy was started daily from the first day of distraction. After 46 ± 8.1 days consolidation, two endosseous implants were inserted and a transmandibular biopsy was taken. Ultrasonographs were taken regularly to follow osteogenesis inside the gap. There were no complications during the 44 ± 7.1 months of follow-up. Microradiographic measurements of the biopsies revealed no differences in the area of mineralized tissue in the distraction gap. The cranially distracted bone segment appeared significantly more radiolucent than the caudal bone. Histological examination showed large lacunae inside the cranially distracted bone segment, filled with clusters of osteoclasts and surrounded by clear tetracycline double labels. Within the distraction gap, woven bone was present, with no apparent differences between the treatment groups. Ultrasonographic follow-up revealed that osteogenesis inside the distraction gap progresses from 4 to 20 weeks post distraction, with no differences between the ultrasound and the placebo groups. In summary, ultrasound treatment does not appear to stimulate bone formation in the severely resorbed vertical distracted mandible.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Septentrionale</li></region><settlement><li>Amsterdam</li></settlement></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Schortinghuis, J" sort="Schortinghuis, J" uniqKey="Schortinghuis J" first="J." last="Schortinghuis">J. Schortinghuis</name></noRegion><name sortKey="Bronckers, A L J J" sort="Bronckers, A L J J" uniqKey="Bronckers A" first="A. L. J. J." last="Bronckers">A. L. J. J. Bronckers</name><name sortKey="Gravendeel, J" sort="Gravendeel, J" uniqKey="Gravendeel J" first="J." last="Gravendeel">J. Gravendeel</name><name sortKey="Raghoebar, G M" sort="Raghoebar, G M" uniqKey="Raghoebar G" first="G. M." last="Raghoebar">G. M. Raghoebar</name><name sortKey="Stegenga, B" sort="Stegenga, B" uniqKey="Stegenga B" first="B." last="Stegenga">B. Stegenga</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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